McMaster University

Scope of Search

Chronic Disease

[View previous projects related to chronic disease]

As Canadians age, many will face a diagnosis with at least one chronic disease.  Conditions such as cardiovascular disease, diabetes, osteoporosis and arthritis are impacting the health and independence of the aging population.

  • Adult Day Service Model
    for Older Adults
  • Prevention and management
    of osteoporosis
  • Polypharmacy Evaluation
    and Reduction
  • Screening Tool for
    Cognitive Impairment

Enhancing optimal aging:  An Examination of a Unique Adult Day Service Model for Older Adults

Resident of Shalom Village with Sharon Kaasalainen and Vanina Dal Bello-Haas
From left: Resident of Shalom Village with Sharon Kaasalainen and Vanina Dal Bello-Haas


Vanina Dal Bello-Haas and Sharon Kaasalainen

Project Description:

Unique Adult Day Services (ADS) models have the potential to become important components in the health care continuum, mitigating the susceptible period of time of discontinuity and potential adverse events for older adults during the transition period from hospital to home. 

This project will:

  • Gain a better understanding of how a unique ADS program targets the needs of older adults
  • Examine short-term and longer-term effects of this program on older adults' function, mobility, resiliency and quality of life

Identifying optimal combinations of nonpharmacological interventions for the prevention and management of osteoporosis and osteoarthritis complications in the elderly: A Bayesian network meta-analysis

Joseph Beyene
Joseph Beyene


Joseph Beyene, Julie Richardson, Parminder Raina, Binod Neupane, Russell de Souza, Alexandra Papaioannou, Aliya Khan

Project Description:

Osteoporosis (OP) and osteoarthritis (OA) are two of the most common health problems that affect mobility and quality of life in aging adults. The risks of these chronic conditions increase dramatically as people age. Several approaches exist for the prevention, treatment and management of complications related to these conditions. Although a wealth of scientific data, based on clinical trials, is available for pharmacological treatments, there is lack of evidence-based studies evaluating the comparative effectiveness and safety of nonpharmacological modalities. Network meta-analysis (NMA) has recently emerged as a powerful analytical technique that allows synthesizing evidence across multiple interventions, estimating the probability of each of the interventions to optimize outcomes.  This project will undertake a comprehensive systematic review and NMA of nonpharmacological interventions for the prevention and management of complications associated with OP and OA in the elderly. Using this methodology, the project team will determine the optimal combination of these interventions for improving physical function and quality of life.

TAPER-F: Team Approach to Polypharmacy Evaluation and Reduction

Dee Mangin, Sherrie Orr and Jenna Parascandalo
From left: Dee Mangin, Sherrie Orr and Jenna Parascandalo


Dee Mangin, Lisa Dolovich, Gina Agarwal, Anne Holbrook, Henry Siu, Cathy Risdon, Julie Richardson, James Gillett, Mat Savelli, James McCormack, Daria O'Reilly, Kiska Colwill, Jane Jurcic, Scott Garrison, Barbara Farrell, Peter Gøtzsche, Johanna Trimble, Alan Cassels, William Brown

Project Description:

Multimorbidity is the most common condition affecting older adults, who take an average of seven regular medications. Adverse drug effects requiring medical care affect 13% of Canadian seniors taking five or more medications; these include falls, cognitive impairment, poor nutrition, fatigue and poor mobility. One-third of these effects are considered preventable. The TAPER project will test a systematic approach to reducing the burden of drugs and the harmful effects of polypharmacy in older adults, while assessing the effects on patient health outcomes including quality of life and functional capacity.  The aim is to enhance the quality of life in seniors by maximizing the beneficial contribution of medications to optimal aging.

A New Screening Tool for Cognitive Impairment

Karin R. Humphreys, Meghan McConnell and Karen Saperson
From left: Karin R. Humphreys, Meghan McConnell and Karen Saperson


Karin R. Humphreys, L. Kathleen Oliver, Meghan McConnell, Karen Saperson

Project Description:

Early detection of cognitive impairment is increasingly important to help optimize outcomes for older adults at risk for dementia.  Current screening tools have some challenges, especially in detecting mild cognitive impairment. This project is working to develop a new behavioural test for screening older adults for mild cognitive impairment.  This test has the potential to be both easier to administer than current tests, and also much less confronting for the individuals being tested.